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Chapter 1 - An Introduction to CAR Immunotherapy
Pages 1-11 - Book chapterAbstract only
Chapter 2 - Components and Design of Chimeric Antigen Receptors
Pages 13-24 - Book chapterAbstract only
Chapter 3 - scFv Cloning, Vectors, and CAR-T Production in Laboratory for Preclinical Applications
Pages 25-49 - Book chapterAbstract only
Chapter 4 - Production of CAR-T Cells for Clinical Applications
Pages 51-62 - Book chapterAbstract only
Chapter 5 - Challenges and Opportunities to Improve CAR T-Cell Therapy
Pages 63-80 - Book chapterNo access
Index
Pages 81-83
About the book
Description
Basics of Chimeric Antigen Receptor (CAR) Immunotherapy presents the latest on how T cell adoptive immunotherapy has progressed in its ultimate goal of curing metastatic malignant cancers. Recent clinical data obtained with checkpoint receptor blockade inhibitors and chimeric antigen receptor (CAR) therapy has been especially promising, thus generating renewed hope that we may be on the verge of finally curing cancer. Over the years, huge progress has been made in controlling several stage IV metastasized cancers through the clinical application of checkpoint receptor inhibitory drugs and CAR-Therapy that has seen unprecedented interest in the immunotherapy field.
Basics of Chimeric Antigen Receptor (CAR) Immunotherapy presents the latest on how T cell adoptive immunotherapy has progressed in its ultimate goal of curing metastatic malignant cancers. Recent clinical data obtained with checkpoint receptor blockade inhibitors and chimeric antigen receptor (CAR) therapy has been especially promising, thus generating renewed hope that we may be on the verge of finally curing cancer. Over the years, huge progress has been made in controlling several stage IV metastasized cancers through the clinical application of checkpoint receptor inhibitory drugs and CAR-Therapy that has seen unprecedented interest in the immunotherapy field.
Key Features
- Presents the first book to provide a basic understanding of chimeric antigen receptor (CARs) design, production and clinical application protocols
- Provides unique authority as the editor has worked directly with CARs
- Discusses the challenges encountered in actual clinical trials and how these challenges can be overcome
- Includes a full chapter on various challenges researchers should expect to encounter in the CAR-therapy field
- Presents the first book to provide a basic understanding of chimeric antigen receptor (CARs) design, production and clinical application protocols
- Provides unique authority as the editor has worked directly with CARs
- Discusses the challenges encountered in actual clinical trials and how these challenges can be overcome
- Includes a full chapter on various challenges researchers should expect to encounter in the CAR-therapy field
Details
ISBN
978-0-12-819573-4
Language
English
Published
2020
Copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
Imprint
Academic Press