Cover for Appetite and Body Weight

Appetite and Body Weight

Integrative Systems and the Development of Anti-Obesity Drugs

Book2007

Edited by:

Tim C. Kirkham and Steven J. Cooper

Appetite and Body Weight

Integrative Systems and the Development of Anti-Obesity Drugs

Book2007

 

Cover for Appetite and Body Weight

Edited by:

Tim C. Kirkham and Steven J. Cooper

Browse this book

Book description

There is now enough basic work to sketch out the principal systems at all levels of the brain, from prefrontal cortex to lower brainstem, which are orchestrated to provide control ... read full description

Browse content

Table of contents

Actions for selected chapters

Select all / Deselect all

  1. Full text access
  2. Book chapterAbstract only

    Chapter 1 - Introduction and Overview

    Steven J. Cooper and Tim C. Kirkham

    Pages 1-4

  3. Book chapterAbstract only

    Chapter 2 - Cortical Systems Involved in Appetite and Food Consumption

    Morten L. Kringelbach

    Pages 5-I

  4. Book chapterAbstract only

    Chapter 3 - The Nucleus Accumbens Shell as a Model of Integrative Subcortical Forebrain Systems Regulating Food Intake

    Thomas R. Stratford

    Pages 27-65

  5. Book chapterAbstract only

    Chapter 4 - Hypothalamic Neuropeptides and Feeding Regulation

    Bernard Beck

    Pages 67-98

  6. Book chapterAbstract only

    Chapter 5 - Brainstem-Hypothalamic Neuropeptides and the Regulation of Feeding

    Simon M. Luckman

    Pages 99-141

  7. Book chapterAbstract only

    Chapter 6 - The Gut-Brain Axis in the Control of Eating

    Thomas A. Lutz and Nori Geary

    Pages 143-166

  8. Book chapterAbstract only

    Chapter 7 - Integration of Peripheral Adiposity Signals and Psychological Controls of Appetite

    Dianne Figlewicz Lattemann, Nicole M. Sanders, ... Alfred J. Sipols

    Pages 167-190

  9. Book chapterAbstract only

    Chapter 8 - Brain Reward Systems for Food Incentives and Hedonics in Normal Appetite and Eating Disorders

    Kent C. Berridge

    Pages 191-II

  10. Book chapterAbstract only

    Chapter 9 - Pharmacology of Food, Taste, and Learned Flavor Preferences

    Steven J. Cooper

    Pages 217-245

  11. Book chapterAbstract only

    Chapter 10 - The Role of Palatability in Control of Human Appetite: Implications for Understanding and Treating Obesity

    Martin R. Yeomans

    Pages 247-269

  12. Book chapterAbstract only

    Chapter 11 - Learned Influences on Appetite, Food Choice, and Intake: Evidence in Human Beings

    E.L. Gibson and J.M. Brunstrom

    Pages 271-300

  13. Book chapterAbstract only

    Chapter 12 - Gene environment Interactions and the Origin of the Modern Obesity Epidemic: A Novel “Nonadaptive Drift” Scenario

    John R. Speakman

    Pages 301-322

  14. Book chapterAbstract only

    Chapter 13 - Preclinical Developments in Antiobesity Drugs

    Steven P. Vickers and Sharon C. Cheetham

    Pages 323-336

  15. Book chapterAbstract only

    Chapter 14 - Clinical Investigations of Antiobesity Drugs

    John Wilding

    Pages 337-III

  16. Book chapterNo access

    Index

    Pages 357-371

About the book

Description

There is now enough basic work to sketch out the principal systems at all levels of the brain, from prefrontal cortex to lower brainstem, which are orchestrated to provide control of food selection, preference and consumption. At the same time, the complex interplay between central systems and signals generated from peripheral systems include the gut, liver and fat stores, as well as the interactions with the neuroendocrine system can be described in some detail. A continuing theme throughout the book is that the functional analysis of appetite and food intake cannot be limited to a single focus, e.g. hypothalamic neuropeptides and their interactions, but must be based on a fully integrated view of the several contributing systems.

Appetite and Body Weight: Integrative Systems and the Development of Anti-Obesity Drugs provides an expert guide to the neural, neurochemical, autonomic and endocrine interrelations which underpin appetite and the controls of food intake and body weight. The book covers many of the neurochemical entities that are currently under investigation, including: neuropeptides, leptin, insulin, monoamines and endogenous cannabinoids in relation to appetite and body-weight control. In addition to the neuroscience analysis, there are also chapters that provide an expert guide to some of the key psychological concepts that the researchers believe are essential in trying to understand the phenomena under investigation. The volume will also serve as an authoritative guide to the current emphasis on the development of novel, efficacious anti-obesity medication.

There is now enough basic work to sketch out the principal systems at all levels of the brain, from prefrontal cortex to lower brainstem, which are orchestrated to provide control of food selection, preference and consumption. At the same time, the complex interplay between central systems and signals generated from peripheral systems include the gut, liver and fat stores, as well as the interactions with the neuroendocrine system can be described in some detail. A continuing theme throughout the book is that the functional analysis of appetite and food intake cannot be limited to a single focus, e.g. hypothalamic neuropeptides and their interactions, but must be based on a fully integrated view of the several contributing systems.

Appetite and Body Weight: Integrative Systems and the Development of Anti-Obesity Drugs provides an expert guide to the neural, neurochemical, autonomic and endocrine interrelations which underpin appetite and the controls of food intake and body weight. The book covers many of the neurochemical entities that are currently under investigation, including: neuropeptides, leptin, insulin, monoamines and endogenous cannabinoids in relation to appetite and body-weight control. In addition to the neuroscience analysis, there are also chapters that provide an expert guide to some of the key psychological concepts that the researchers believe are essential in trying to understand the phenomena under investigation. The volume will also serve as an authoritative guide to the current emphasis on the development of novel, efficacious anti-obesity medication.

Key Features

  • Provides an integrative view of the many systems involved in appetite how they interact to effect food intake (i.e. the brain, endocrine, gut, liver etc.)
  • Considers psychological aspects such as incentive, preference, liking and palatability, and sets these concepts in their behavioural, pharmacological and neural contexts
  • Examines the development of novel anti-obesity drugs, drawing on experience of pharmacological development work, pre-clinical tests for anti-obesity efficacy, and clinical trials of candidate anti-obesity compounds
  • Provides an integrative view of the many systems involved in appetite how they interact to effect food intake (i.e. the brain, endocrine, gut, liver etc.)
  • Considers psychological aspects such as incentive, preference, liking and palatability, and sets these concepts in their behavioural, pharmacological and neural contexts
  • Examines the development of novel anti-obesity drugs, drawing on experience of pharmacological development work, pre-clinical tests for anti-obesity efficacy, and clinical trials of candidate anti-obesity compounds

Details

ISBN

978-0-12-370633-1

Language

English

Published

2007

Copyright

Copyright © 2007 Elsevier Inc. All rights reserved

Imprint

Academic Press

You currently don’t have access to this book, however you can purchase separate chapters directly from the table of contents or buy the full version.

Purchase the book

Editors

Tim C. Kirkham

University of Liverpool, School of Psychology, Liverpool, UK

Steven J. Cooper

University of Liverpool, School of Psychology, Liverpool, UK