Cover for Anticandidal Agents

Anticandidal Agents

Book2017

Authors:

Awanish Kumar and Anubhuti Jha

Anticandidal Agents

Book2017

 

Cover for Anticandidal Agents

Authors:

Awanish Kumar and Anubhuti Jha

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Anticandidal Agents provides the latest information on candida drug resistance and its remedial implications. In this compilation, users will find a comprehensive view on overcomin ... read full description

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  2. Book chapterAbstract only

    Chapter 1 - Introduction

    Pages 1-5

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    Chapter 2 - Host–Pathogen Interaction

    Pages 7-10

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    Chapter 3 - Antifungals Used Against Candidiasis

    Pages 11-39

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    Chapter 4 - Drug Resistance in Candida

    Pages 41-47

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    Chapter 5 - Multidrug Resistance and Transporters

    Pages 49-54

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    Chapter 6 - Potential Anticandidal Targets

    Pages 55-61

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    Chapter 7 - Drug Development Strategies

    Pages 63-71

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    Chapter 8 - Conclusion

    Pages 73-74

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    Abbreviations

    Pages 75-76

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    Bibliography

    Pages 77-83

About the book

Description

Anticandidal Agents provides the latest information on candida drug resistance and its remedial implications. In this compilation, users will find a comprehensive view on overcoming resistance in anticandidal drugs, along with information on novel molecules.

Candida albicans is an opportunistic pathogenic fungus responsible for life threating invasive and nosocomial infections across the globe. Candidiasis is a major cause of morbidity among immunocompromised patients. Infections caused by non-albicans candida like C. glabrata, C. parapsilosis, and C. tropicalis have also imposed a serious threat in the last few decades. Current treatment of candidiasis relies primarily on antifungal agents broadly categorized as azoles, polyenes, echinocandins, allylamines, and pyrimidines.

Lately, antifungal resistance has emerged to be an obstruction of current treatment regime. A number of reasons are described in detail. Understanding the mechanisms of resistance is crucial for developing strategies for overcoming the hindrance in current therapeutics.

Anticandidal Agents provides the latest information on candida drug resistance and its remedial implications. In this compilation, users will find a comprehensive view on overcoming resistance in anticandidal drugs, along with information on novel molecules.

Candida albicans is an opportunistic pathogenic fungus responsible for life threating invasive and nosocomial infections across the globe. Candidiasis is a major cause of morbidity among immunocompromised patients. Infections caused by non-albicans candida like C. glabrata, C. parapsilosis, and C. tropicalis have also imposed a serious threat in the last few decades. Current treatment of candidiasis relies primarily on antifungal agents broadly categorized as azoles, polyenes, echinocandins, allylamines, and pyrimidines.

Lately, antifungal resistance has emerged to be an obstruction of current treatment regime. A number of reasons are described in detail. Understanding the mechanisms of resistance is crucial for developing strategies for overcoming the hindrance in current therapeutics.

Key Features

  • Presents a complete understanding of candida resistance to help in the development of therapeutic expansion and novel drugs
  • Provides thorough information on candida drug resistance and its remedial implications
  • Covers crucial mechanisms of resistance that will help develop strategies for overcoming the hindrance in current therapeutics
  • Presents a complete understanding of candida resistance to help in the development of therapeutic expansion and novel drugs
  • Provides thorough information on candida drug resistance and its remedial implications
  • Covers crucial mechanisms of resistance that will help develop strategies for overcoming the hindrance in current therapeutics

Details

ISBN

978-0-12-811311-0

Language

English

Published

2017

Copyright

Copyright © 2017 Elsevier Inc. All rights reserved.

Imprint

Academic Press

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Authors

Awanish Kumar

Assistant Professor, Department of Biotechnology, National Institute of Technology, Raipur, Chhattisgarh, India

Anubhuti Jha

Department of Biotechnology, National Institute of Technology, Raipur, Chhattisgarh, India