Cover for Aluminium and Alzheimer's Disease

Aluminium and Alzheimer's Disease

The Science that Describes the Link

Book2001

Edited by:

Christopher Exley

Aluminium and Alzheimer's Disease

The Science that Describes the Link

Book2001

 

Cover for Aluminium and Alzheimer's Disease

Edited by:

Christopher Exley

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Book description

The subject of aluminium and Alzheimer's disease has been plagued with controversy. This controversy has served to obscure much of the scientific research in this field, and subseq ... read full description

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  2. Book chapterNo access

    Chapter 1 - Aluminium Induced Disease in Subjects with and without Renal Failure—Does It Help Us Understand the Role of Aluminium in Alzheimer’s Disease?

    Paul Altmann

    Pages 1-36

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    Chapter 2 - Aluminum-Induced Bone Disease: Implications for Alzheimer’s Disease

    Kenneth Abreo

    Pages 37-57

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    Chapter 3 - The Epidemiology of Aluminium and Alzheimer’s Disease

    Virginie Rondeau and Daniel Commenges

    Pages 59-73

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    Chapter 4 - Absorption of Aluminum from Antiperspirants and Vaccine Adjuvants

    Richard Flarend

    Pages 75-95

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    Chapter 5 - The Aetiology of Alzheimer’s Disease: Diverse Routes into a Common Tau Pathway

    Charles R. Harrington

    Pages 97-132

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    Chapter 6 - The Association of Aluminum and Neurofibrillary Degeneration in Alzheimer’s Disease, a Personal Perspective

    Daniel P. Perl

    Pages 133-146

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    Chapter 7 - Aluminum and Gene Transcription in the Mammalian Central Nervous System — Implications for Alzheimer's Disease

    Walter J. Lukiw

    Pages 147-168

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    Chapter 8 - Behavioral Studies in Animals: Past and Potential Contribution to the Understanding of the Relationship between Aluminum and Alzheimer’s Disease

    MariS. Golub

    Pages 169-187

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    Chapter 9 - Aluminum as an Experimental Neurotoxicant: The Neuropathology and Neurochemistry

    Michael J. Strong

    Pages 189-202

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    Chapter 10 - The Rabbit Model System for Studies of Aluminum-Induced Neurofibrillary Degeneration: Relevance to Human Neurodegenerative Disorders

    John Savory, Othman Ghribi, ... Mary M. Herman

    Pages 203-219

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    Chapter 11 - Aluminium Iron: Implications for Alzheimer’s Disease

    Patrick C. D'Haese and Marc E. De Broe

    Pages 221-231

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    Chapter 12 - Aluminum and the Blood-Brain Barrier

    Robert A. Yokel

    Pages 233-260

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    CHAPTER 13 - Aluminium Toxicity in Erythropoiesis. Mechanisms Related to Cellular Dysfunction in Alzheimer’s Disease

    Alcira Nesse and Graciela Garbossa

    Pages 261-277

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    CHAPTER 14 - Aluminum, Membranes and Alzheimer’s Disease

    Paolo Zatta and Mario Suwalsky

    Pages 279-291

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    Chapter 15 - Iron Homeostasis and Aluminium Toxicity

    Roberta J. Ward and Robert R. Crichton

    Pages 293-310

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    Chapter 16 - Oxidative and Inflammatory Properties of Aluminum: Possible Relevance in Alzheimer’s Disease

    Stephen C. Bondy and Arezoo Campbell

    Pages 311-321

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    CHAPTER 17 - Glutamatergic Neurotransmission, Aluminium and Alzheimer’s Disease

    Vicente Felipo

    Pages 323-344

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    Chapter 18 - Aluminum-Induced Alteration of Phosphoinositide and Calcium Signaling

    William R. Mundy and Timothy J. Shafer

    Pages 345-360

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    CHAPTER 19 - The Interaction of Aluminium with Peptides and Proteins

    Tamás Kiss and Miklós Hollósi

    Pages 361-392

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    Chapter 20 - Calmodulin, Aluminium and Alzheimer’s Disease

    Beka Solomon

    Pages 393-409

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    Chapter 21 - Aluminum, Tau and Neurofibrillary Degeneration

    Ryong-Woon Shin

    Pages 411-420

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    Chapter 22 - The Association of Aluminium and β Amyloid in Alzheimer’s Disease

    Christopher Exley and Olga Korchazhkina

    Pages 421-433

  24. Book chapterNo access

    List of Contributors

    Kenneth Abreo, Paul Altmann, ... Paolo Zatta

    Pages 435-437

  25. Book chapterNo access

    Keyword Index

    Pages 439-441

About the book

Description

The subject of aluminium and Alzheimer's disease has been plagued with controversy. This controversy has served to obscure much of the scientific research in this field, and subsequently has obscured the possibility that aluminium is a contributory factor in the aetiology of Alzheimer's disease.


This book brings together many of the world's leading scientists researching aluminium and life and contains their critical summaries on the known facts about aluminium toxicity in man and to offer an opinion on the implications of this knowledge on a link between aluminium and Alzheimer's disease. The subject areas of the chapters were chosen to reflect the myriad of ways that aluminium is known to impact upon mammalian physiology and function and range from clinical studies, through animal models of disease to the detailed biochemistry of aluminium toxicity. Chapters are also included on epidemiology and other factors involved in the aetiology of Alzheimer's.


This is the first time that this subject has been treated in such a comprehensive manner. The research detailed in each chapter, includes the latest research in the field, it has been critically appraised and this appraisal has been used by each author to present an informed opinion of its relevance to aluminium and Alzheimer's disease. The chapters are much more than reviews; they are a statement of the state of the art and of what the future may hold for research in this field. As a whole they show the high quality of research that has been carried out in our efforts to understand the toxicity of aluminium in man and that we are far away from discounting the possibility that aluminium is a contributory factor in the aetiology of Alzheimer's disease.

The subject of aluminium and Alzheimer's disease has been plagued with controversy. This controversy has served to obscure much of the scientific research in this field, and subsequently has obscured the possibility that aluminium is a contributory factor in the aetiology of Alzheimer's disease.


This book brings together many of the world's leading scientists researching aluminium and life and contains their critical summaries on the known facts about aluminium toxicity in man and to offer an opinion on the implications of this knowledge on a link between aluminium and Alzheimer's disease. The subject areas of the chapters were chosen to reflect the myriad of ways that aluminium is known to impact upon mammalian physiology and function and range from clinical studies, through animal models of disease to the detailed biochemistry of aluminium toxicity. Chapters are also included on epidemiology and other factors involved in the aetiology of Alzheimer's.


This is the first time that this subject has been treated in such a comprehensive manner. The research detailed in each chapter, includes the latest research in the field, it has been critically appraised and this appraisal has been used by each author to present an informed opinion of its relevance to aluminium and Alzheimer's disease. The chapters are much more than reviews; they are a statement of the state of the art and of what the future may hold for research in this field. As a whole they show the high quality of research that has been carried out in our efforts to understand the toxicity of aluminium in man and that we are far away from discounting the possibility that aluminium is a contributory factor in the aetiology of Alzheimer's disease.

Details

ISBN

978-0-444-50811-9

Language

English

Published

2001

Copyright

Copyright © 2001 Elsevier B.V. All rights reserved

Imprint

Elsevier Science

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Editors

Christopher Exley

Birchall Centre for Inorganic Chemistry and Materials Science, School of Chemistry and Physics, Keele University, Staffordshire, ST5 5BG, UK