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Chapter 1 - Adenovirus Structure
Phoebe L. Stewart
Pages 1-18 - Book chapterAbstract only
Chapter 2 - Biology of Adenovirus Cell Entry
Glen R. Nemerow
Pages 19-38 - Book chapterAbstract only
Chapter 3 - Adenovirus Replication
Jared D. Evans and Patrick Hearing
Pages 39-70 - Book chapterAbstract only
Chapter 4 - Adenoviral Vector Construction I: Mammalian Systems
Philip Ng and Frank L. Graham
Pages 71-104 - Book chapterAbstract only
Chapter 5 - Adenoviral Vector Construction II: Bacterial Systems
M. Lusky, E. Degryse, ... C. Chartier
Pages 105-127 - Book chapterAbstract only
Chapter 6 - Propagation of Adenoviral Vectors: Use of PER. C6 Cells
W.W. Nichols, R. Lardenoije, ... A. Bout
Pages 129-166 - Book chapterAbstract only
Chapter 7 - Purification of Adenovirus
Paul Shabram, Gary Vellekamp and Carl Scandella
Pages 167-203 - Book chapterAbstract only
Chapter 8 - Targeted Adenoviral Vectors I: Transductional Targeting
Victor Krasnykh and Joanne T. Douglas
Pages 205-245 - Book chapterAbstract only
Chapter 9 - Targeted Adenoviral Vectors II: Transcriptional Targeting
Sudhanshu P. Raikwar, Chinghai H. Kao and Thomas A. Gardner
Pages 247-286 - Book chapterAbstract only
Chapter 10 - Development of Attenuated Replication Competent Adenoviruses (ARCAs) for the Treatment of Prostate Cancer
Daniel R. Henderson and De-Chao Yu
Pages 287-328 - Book chapterAbstract only
Chapter 11 - Replication-Selective Oncolytic Adenovirus E1-Region Mutants: Virotherapy for Cancer
David Kirn
Pages 329-348 - Book chapterAbstract only
Chapter 12 - Innate Immune Responses to in Vivo Adenovirus Infection
Bruce C. Trapnell and Thomas P. Shanley
Pages 349-373 - Book chapterAbstract only
Chapter 13 - Humoral Immune Response
Catherine O'Riordan
Pages 375-407 - Book chapterAbstract only
Chapter 14 - Novel Methods to Eliminate the Immune Response to Adenovirus Gene Therapy
Huang-Ge Zhang, Hui-Chen Hsu and John D. Mountz
Pages 409-428 - Book chapterAbstract only
Chapter 15 - High-Capacity “Gutless” Adenoviral Vectors: Technical Aspects and Applications
Gudrun Schiedner, Paula R. Clemens, ... Stefan Kochanek
Pages 429-446 - Book chapterAbstract only
Chapter 16 - Xenogenic Adenoviral Vectors
Gerald W. Both
Pages 447-479 - Book chapterAbstract only
Chapter 17 - Hybrid Adenoviral Vectors
Stephen J. Murphy and Richard G. Vile
Pages 481-531 - Book chapterAbstract only
Chapter 18 - Utility of Adenoviral Vectors in Animal Models of Human Disease I: Cancer
Raj K. Batra, Sherven Sharma and Lily Wu
Pages 533-563 - Book chapterAbstract only
Chapter 19 - Utility of Adenoviral Vectors in Animal Models of Human Disease II: Genetic Disease
Raymond John Pickles
Pages 565-594 - Book chapterAbstract only
Chapter 20 - Utility of Adenoviral Vectors in Animal Models of Human Disease III: Acquired Diseases
Erik Lubberts and Jay K. Kolls
Pages 595-613 - Book chapterAbstract only
Chapter 21 - Testing of Adenoviral Vector Gene Transfer Products: FDA Expectations
Steven R. Bauer, Anne M. Pilaro and Karen D. Weiss
Pages 615-654 - Book chapterAbstract only
Chapter 22 - Imaging Adenovirus-Mediated Gene Transfer
Kurt R. Zinn and Tandra R. Chaudhuri
Pages 655-677 - Book chapterNo access
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Pages I-XII
About the book
Description
Adenoviral Vectors for Gene Therapy provides detailed and comprehensive coverage of these important therapeutic agents. The topics covered in this book range from the basic biology of adenoviruses, through the construction and purification of adenoviral vectors, cutting-edge vectorology and the use of adenoviral vectors in preclinical animal models, to regulatory issues which must be considered prior to the initiation of human clinical gene therapy trials. The broad scope of this unique volume provides the reader with a complete understanding of the development and use of adenoviral vectors.
Adenoviral Vectors for Gene Therapy provides detailed and comprehensive coverage of these important therapeutic agents. The topics covered in this book range from the basic biology of adenoviruses, through the construction and purification of adenoviral vectors, cutting-edge vectorology and the use of adenoviral vectors in preclinical animal models, to regulatory issues which must be considered prior to the initiation of human clinical gene therapy trials. The broad scope of this unique volume provides the reader with a complete understanding of the development and use of adenoviral vectors.
Key Features
@introbul:Key Features
@bul:* Provides complete coverage of basic biology of adenoviruses, as well as the construction, propagation and purification of adenoviral vectors
* Introduces common strategies for the development of adenoviral vectors along with cutting-edge methods for their improvement
* Demonstrates noninvasive imaging of adenovirus-mediated gene transfer
* Discusses utility of adenoviral vectors in animal disease models
* Considers Federal Drug Administration regulations for human clinical trials
@introbul:Key Features
@bul:* Provides complete coverage of basic biology of adenoviruses, as well as the construction, propagation and purification of adenoviral vectors
* Introduces common strategies for the development of adenoviral vectors along with cutting-edge methods for their improvement
* Demonstrates noninvasive imaging of adenovirus-mediated gene transfer
* Discusses utility of adenoviral vectors in animal disease models
* Considers Federal Drug Administration regulations for human clinical trials
Details
ISBN
978-0-12-199504-1
Language
English
Published
2002
Copyright
Copyright © 2002 Elsevier Inc. All rights reserved
Imprint
Academic Press