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1 - Adenovirus Structure
Phoebe L. Stewart
Pages 1-26 - Book chapterAbstract only
2 - Biology of Adenovirus Cell Entry: Receptors, Pathways, Mechanisms
Stefania Luisoni and Urs F. Greber
Pages 27-58 - Book chapterAbstract only
3 - Adenovirus Replication
Diana Guimet and Patrick Hearing
Pages 59-84 - Book chapterAbstract only
4 - Adenoviral Vector Construction I: Mammalian Systems
Shyambabu Chaurasiya and Mary M. Hitt
Pages 85-112 - Book chapterAbstract only
5 - Adenoviral Vector Construction II: Bacterial Systems
Masahisa Hemmi and Hiroyuki Mizuguchi
Pages 113-137 - Book chapterAbstract only
6 - Upstream Bioprocess for Adenovirus Vectors
P. Fernandes, A.C. Silva, ... P.M. Alves
Pages 139-161 - Book chapterAbstract only
7 - Propagation of Adenoviral Vectors: Use of PER.C6™ Cells
W.W. Nichols, R. Lardenoije, ... A. Bout
Pages 163-196 - Book chapterAbstract only
8 - Purification of Adenovirus
Paul Shabram, Gary Vellekamp, ... Carl Scandella
Pages 197-230 - Book chapterAbstract only
9 - Targeted Adenoviral Vectors I: Transductional Targeting
Igor P. Dmitriev and Sergey A. Kaliberov
Pages 231-257 - Book chapterAbstract only
10 - Targeted Adenoviral Vectors III: Transcriptional Targeting
Sudhanshu P. Raikwar, Chinghai H. Kao and Thomas A. Gardner
Pages 259-292 - Book chapterAbstract only
11 - Adenoviral Vector Targeting via Mitigation of Liver Sequestration
Michael A. Barry
Pages 293-317 - Book chapterAbstract only
12 - Molecular Design of Oncolytic Adenoviruses
Ramon Alemany
Pages 319-334 - Book chapterAbstract only
13 - Conditionally Replicative Adenoviruses—Clinical Trials
Enric Xipell, Yisel Rivera-Molina, ... Juan Fueyo
Pages 335-348 - Book chapterAbstract only
14 - Innate Immune Response to Adenovirus Vector Administration In Vivo
Svetlana Atasheva and Dmitry M. Shayakhmetov
Pages 349-366 - Book chapterAbstract only
15 - Antibodies against Adenoviruses
Andrew P. Byrnes
Pages 367-390 - Book chapterAbstract only
16 - Methods to Mitigate Immune Responses to Adenoviral Vectors
Yasser A. Aldhamen and Andrea Amalfitano
Pages 391-422 - Book chapterAbstract only
17 - Helper-Dependent Adenoviral Vectors
Nicola Brunetti-Pierri and Philip Ng
Pages 423-450 - Book chapterAbstract only
18 - Hybrid Adenoviral Vectors
Stephen J. Murphy and Richard G. Vile
Pages 451-493 - Book chapterAbstract only
19 - Xenogenic Adenoviral Vectors
Suresh K. Mittal, Yadvinder S. Ahi and Sai V. Vemula
Pages 495-528 - Book chapterAbstract only
20 - Engineering Chimeric Adenoviruses: Exploiting Virus Diversity for Improved Vectors, Vaccines, and Oncolytics
Johanna K. Kaufmann and Dirk M. Nettelbeck
Pages 529-549 - Book chapterAbstract only
21 - Adenoviral Vector Vaccines Antigen Transgene
Hildegund C.J. Ertl
Pages 551-570 - Book chapterAbstract only
22 - Adenoviral Vectors Vaccine: Capsid Incorporation of Antigen
Anurag Sharma and Stefan Worgall
Pages 571-590 - Book chapterAbstract only
23 - Utility of Adenoviral Vectors in Animal Models of Human Disease I: Cancer
Raj K. Batra, Sherven Sharma and Lily Wu
Pages 591-617 - Book chapterAbstract only
24 - In Situ Vaccination with Adenoviral Vectors to Treat Cancer
Steven M. Albelda and Edmund Moon
Pages 619-633 - Book chapterAbstract only
25 - Utility of Adenoviral Vectors in Animal Models of Human Disease II: Genetic Disease
Raymond John Pickles
Pages 635-661 - Book chapterAbstract only
26 - Adenoviral Vectors for Pulmonary Disease (Pulmonary Vascular Disease)
Paul N. Reynolds
Pages 663-674 - Book chapterAbstract only
27 - Utility of Adenoviral Vectors in Animal Models of Human Disease III: Acquired Diseases
Erik Lubberts and Jay K. Kolls
Pages 675-690 - Book chapterAbstract only
28 - Animal Models of Gene Therapy for Cardiovascular Disease
Johanna P. Laakkonen and Seppo Ylä-Herttuala
Pages 691-705 - Book chapterAbstract only
29 - Polymer-Anchored Adenovirus as a Therapeutic Agent for Cancer Gene Therapy
Dayananda Kasala and Chae-Ok Yun
Pages 707-737 - Book chapterAbstract only
30 - Adenoviral Vectors for RNAi Delivery
Hideyo Ugai
Pages 739-765 - Book chapterAbstract only
31 - Imaging and Adenoviral Gene Therapy
Jillian R. Richter, Benjamin B. Kasten and Kurt R. Zinn
Pages 767-802 - Book chapterAbstract only
32 - Regulation of Adenoviral Vector-Based Therapies: An FDA Perspective
Michael Havert, Rachael Anatol, ... Ying Huang
Pages 803-832 - Book chapterNo access
Index
Pages 833-848
About the book
Description
Adenoviral Vectors for Gene Therapy, Second Edition provides detailed, comprehensive coverage of the gene delivery vehicles that are based on the adenovirus that is emerging as an important tool in gene therapy. These exciting new therapeutic agents have great potential for the treatment of disease, making gene therapy a fast-growing field for research.
This book presents topics ranging from the basic biology of adenoviruses, through the construction and purification of adenoviral vectors, cutting-edge vectorology, and the use of adenoviral vectors in preclinical animal models, with final consideration of the regulatory issues surrounding human clinical gene therapy trials. This broad scope of information provides a solid overview of the field, allowing the reader to gain a complete understanding of the development and use of adenoviral vectors.
Adenoviral Vectors for Gene Therapy, Second Edition provides detailed, comprehensive coverage of the gene delivery vehicles that are based on the adenovirus that is emerging as an important tool in gene therapy. These exciting new therapeutic agents have great potential for the treatment of disease, making gene therapy a fast-growing field for research.
This book presents topics ranging from the basic biology of adenoviruses, through the construction and purification of adenoviral vectors, cutting-edge vectorology, and the use of adenoviral vectors in preclinical animal models, with final consideration of the regulatory issues surrounding human clinical gene therapy trials. This broad scope of information provides a solid overview of the field, allowing the reader to gain a complete understanding of the development and use of adenoviral vectors.
Key Features
- Provides complete coverage of the basic biology of adenoviruses, as well as their construction, propagation, and purification of adenoviral vectors
- Introduces common strategies for the development of adenoviral vectors, along with cutting-edge methods for their improvement
- Demonstrates noninvasive imaging of adenovirus-mediated gene transfer
- Discusses utility of adenoviral vectors in animal disease models
- Considers Federal Drug Administration regulations for human clinical trials
- Provides complete coverage of the basic biology of adenoviruses, as well as their construction, propagation, and purification of adenoviral vectors
- Introduces common strategies for the development of adenoviral vectors, along with cutting-edge methods for their improvement
- Demonstrates noninvasive imaging of adenovirus-mediated gene transfer
- Discusses utility of adenoviral vectors in animal disease models
- Considers Federal Drug Administration regulations for human clinical trials
Details
ISBN
978-0-12-800276-6
Language
English
Published
2016
Copyright
Copyright © 2016 Elsevier Inc. All rights reserved.
Imprint
Academic Press