Cover for Adenoviral Vectors for Gene Therapy

Adenoviral Vectors for Gene Therapy

Book • Second Edition2016

Edited by:

David T. Curiel

Adenoviral Vectors for Gene Therapy

Book • Second Edition2016

 

Cover for Adenoviral Vectors for Gene Therapy

Edited by:

David T. Curiel

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Adenoviral Vectors for Gene Therapy, Second Edition provides detailed, comprehensive coverage of the gene delivery vehicles that are based on the adenovirus that is emerging as an ... read full description

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  2. Book chapterAbstract only

    1 - Adenovirus Structure

    Phoebe L. Stewart

    Pages 1-26

  3. Book chapterAbstract only

    2 - Biology of Adenovirus Cell Entry: Receptors, Pathways, Mechanisms

    Stefania Luisoni and Urs F. Greber

    Pages 27-58

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    3 - Adenovirus Replication

    Diana Guimet and Patrick Hearing

    Pages 59-84

  5. Book chapterAbstract only

    4 - Adenoviral Vector Construction I: Mammalian Systems

    Shyambabu Chaurasiya and Mary M. Hitt

    Pages 85-112

  6. Book chapterAbstract only

    5 - Adenoviral Vector Construction II: Bacterial Systems

    Masahisa Hemmi and Hiroyuki Mizuguchi

    Pages 113-137

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    6 - Upstream Bioprocess for Adenovirus Vectors

    P. Fernandes, A.C. Silva, ... P.M. Alves

    Pages 139-161

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    7 - Propagation of Adenoviral Vectors: Use of PER.C6™ Cells

    W.W. Nichols, R. Lardenoije, ... A. Bout

    Pages 163-196

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    8 - Purification of Adenovirus

    Paul Shabram, Gary Vellekamp, ... Carl Scandella

    Pages 197-230

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    9 - Targeted Adenoviral Vectors I: Transductional Targeting

    Igor P. Dmitriev and Sergey A. Kaliberov

    Pages 231-257

  11. Book chapterAbstract only

    10 - Targeted Adenoviral Vectors III: Transcriptional Targeting

    Sudhanshu P. Raikwar, Chinghai H. Kao and Thomas A. Gardner

    Pages 259-292

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    11 - Adenoviral Vector Targeting via Mitigation of Liver Sequestration

    Michael A. Barry

    Pages 293-317

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    12 - Molecular Design of Oncolytic Adenoviruses

    Ramon Alemany

    Pages 319-334

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    13 - Conditionally Replicative Adenoviruses—Clinical Trials

    Enric Xipell, Yisel Rivera-Molina, ... Juan Fueyo

    Pages 335-348

  15. Book chapterAbstract only

    14 - Innate Immune Response to Adenovirus Vector Administration In Vivo

    Svetlana Atasheva and Dmitry M. Shayakhmetov

    Pages 349-366

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    15 - Antibodies against Adenoviruses

    Andrew P. Byrnes

    Pages 367-390

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    16 - Methods to Mitigate Immune Responses to Adenoviral Vectors

    Yasser A. Aldhamen and Andrea Amalfitano

    Pages 391-422

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    17 - Helper-Dependent Adenoviral Vectors

    Nicola Brunetti-Pierri and Philip Ng

    Pages 423-450

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    18 - Hybrid Adenoviral Vectors

    Stephen J. Murphy and Richard G. Vile

    Pages 451-493

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    19 - Xenogenic Adenoviral Vectors

    Suresh K. Mittal, Yadvinder S. Ahi and Sai V. Vemula

    Pages 495-528

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    20 - Engineering Chimeric Adenoviruses: Exploiting Virus Diversity for Improved Vectors, Vaccines, and Oncolytics

    Johanna K. Kaufmann and Dirk M. Nettelbeck

    Pages 529-549

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    21 - Adenoviral Vector Vaccines Antigen Transgene

    Hildegund C.J. Ertl

    Pages 551-570

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    22 - Adenoviral Vectors Vaccine: Capsid Incorporation of Antigen

    Anurag Sharma and Stefan Worgall

    Pages 571-590

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    23 - Utility of Adenoviral Vectors in Animal Models of Human Disease I: Cancer

    Raj K. Batra, Sherven Sharma and Lily Wu

    Pages 591-617

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    24 - In Situ Vaccination with Adenoviral Vectors to Treat Cancer

    Steven M. Albelda and Edmund Moon

    Pages 619-633

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    25 - Utility of Adenoviral Vectors in Animal Models of Human Disease II: Genetic Disease

    Raymond John Pickles

    Pages 635-661

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    26 - Adenoviral Vectors for Pulmonary Disease (Pulmonary Vascular Disease)

    Paul N. Reynolds

    Pages 663-674

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    27 - Utility of Adenoviral Vectors in Animal Models of Human Disease III: Acquired Diseases

    Erik Lubberts and Jay K. Kolls

    Pages 675-690

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    28 - Animal Models of Gene Therapy for Cardiovascular Disease

    Johanna P. Laakkonen and Seppo Ylä-Herttuala

    Pages 691-705

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    29 - Polymer-Anchored Adenovirus as a Therapeutic Agent for Cancer Gene Therapy

    Dayananda Kasala and Chae-Ok Yun

    Pages 707-737

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    30 - Adenoviral Vectors for RNAi Delivery

    Hideyo Ugai

    Pages 739-765

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    31 - Imaging and Adenoviral Gene Therapy

    Jillian R. Richter, Benjamin B. Kasten and Kurt R. Zinn

    Pages 767-802

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    32 - Regulation of Adenoviral Vector-Based Therapies: An FDA Perspective

    Michael Havert, Rachael Anatol, ... Ying Huang

    Pages 803-832

  34. Book chapterNo access

    Index

    Pages 833-848

About the book

Description

Adenoviral Vectors for Gene Therapy, Second Edition provides detailed, comprehensive coverage of the gene delivery vehicles that are based on the adenovirus that is emerging as an important tool in gene therapy. These exciting new therapeutic agents have great potential for the treatment of disease, making gene therapy a fast-growing field for research.

This book presents topics ranging from the basic biology of adenoviruses, through the construction and purification of adenoviral vectors, cutting-edge vectorology, and the use of adenoviral vectors in preclinical animal models, with final consideration of the regulatory issues surrounding human clinical gene therapy trials. This broad scope of information provides a solid overview of the field, allowing the reader to gain a complete understanding of the development and use of adenoviral vectors.

Adenoviral Vectors for Gene Therapy, Second Edition provides detailed, comprehensive coverage of the gene delivery vehicles that are based on the adenovirus that is emerging as an important tool in gene therapy. These exciting new therapeutic agents have great potential for the treatment of disease, making gene therapy a fast-growing field for research.

This book presents topics ranging from the basic biology of adenoviruses, through the construction and purification of adenoviral vectors, cutting-edge vectorology, and the use of adenoviral vectors in preclinical animal models, with final consideration of the regulatory issues surrounding human clinical gene therapy trials. This broad scope of information provides a solid overview of the field, allowing the reader to gain a complete understanding of the development and use of adenoviral vectors.

Key Features

  • Provides complete coverage of the basic biology of adenoviruses, as well as their construction, propagation, and purification of adenoviral vectors
  • Introduces common strategies for the development of adenoviral vectors, along with cutting-edge methods for their improvement
  • Demonstrates noninvasive imaging of adenovirus-mediated gene transfer
  • Discusses utility of adenoviral vectors in animal disease models
  • Considers Federal Drug Administration regulations for human clinical trials
  • Provides complete coverage of the basic biology of adenoviruses, as well as their construction, propagation, and purification of adenoviral vectors
  • Introduces common strategies for the development of adenoviral vectors, along with cutting-edge methods for their improvement
  • Demonstrates noninvasive imaging of adenovirus-mediated gene transfer
  • Discusses utility of adenoviral vectors in animal disease models
  • Considers Federal Drug Administration regulations for human clinical trials

Details

ISBN

978-0-12-800276-6

Language

English

Published

2016

Copyright

Copyright © 2016 Elsevier Inc. All rights reserved.

Imprint

Academic Press

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Editors

David T. Curiel