Cover for Acute Toxicology Testing

Acute Toxicology Testing

Book • Second Edition1998

Authors:

Shayne C. Gad and Christopher P. Chengelis

Acute Toxicology Testing

Book • Second Edition1998

 

Cover for Acute Toxicology Testing

Authors:

Shayne C. Gad and Christopher P. Chengelis

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Book description

Acute toxicology testing provides the first line of defense against potentially dangerous chemicals. This book is a complete and practical guide to conducting and interpreting all ... read full description

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  2. Book chapterNo access

    CHAPTER 1 - Introduction

    Pages 1-15

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    CHAPTER 2 - Acute Toxicology Program: Study Design and Development

    Pages 17-30

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    CHAPTER 3 - Tests for Dermal Irritation and Corrosion

    Pages 31-56

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    CHAPTER 4 - Ocular Irritation Testing

    Pages 57-84

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    CHAPTER 5 - Dermal Sensitization

    Pages 85-125

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    CHAPTER 6 - Photosensitization and Phototoxicity

    Pages 127-153

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    CHAPTER 7 - Lethality Testing

    Pages 155-196

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    CHAPTER 8 - Safety Considerations for the Administration of Agents by the Parenteral Routes

    Pages 197-220

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    CHAPTER 9 - Systemic Acute Toxicity Testing

    Pages 221-256

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    CHAPTER 10 - Routes, Formulations, and Vehicles

    Pages 257-303

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    CHAPTER 11 - Considerations Specific to Animal Test Models

    Pages 305-360

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    CHAPTER 12 - Statistical Analysis of Acute Toxicology and Safety Studies

    Pages 361-402

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    CHAPTER 13 - Acute Inhalation

    Pages 403-465

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    CHAPTER 14 - Problems and Issues

    Pages 467-492

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    APPENDIX A - Common Regulatory and Toxicological Acronyms

    Pages 493-494

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    APPENDIX B - Table for Calculation of Median Effective Dose by Moving Average

    Pages 495-515

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    APPENDIX C - Vehicles

    Pages 517-524

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    APPENDIX D - Definition of Terms and Lexicon of Clinical Observations

    Pages 525-527

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    INDEX

    Pages 529-534

About the book

Description

Acute toxicology testing provides the first line of defense against potentially dangerous chemicals. This book is a complete and practical guide to conducting and interpreting all regulatory required and commonly used acute toxicity tests. It presents detailed protocols for all of the common test designs and reviews their development and objectives. Acute Toxicology Testing, Second Edition will interest not only workers in the pharmaceutical industry, but also researchers and students in toxicology and public health.

Acute toxicology testing provides the first line of defense against potentially dangerous chemicals. This book is a complete and practical guide to conducting and interpreting all regulatory required and commonly used acute toxicity tests. It presents detailed protocols for all of the common test designs and reviews their development and objectives. Acute Toxicology Testing, Second Edition will interest not only workers in the pharmaceutical industry, but also researchers and students in toxicology and public health.

Key Features

@introbul:Key Features
@bul:* Over 100 tables summarizing and interpreting results
* Complete coverage of all major test designs and their limitations and advantages
* Current status of alternative test designs and models

@introbul:Key Features
@bul:* Over 100 tables summarizing and interpreting results
* Complete coverage of all major test designs and their limitations and advantages
* Current status of alternative test designs and models

Details

ISBN

978-0-12-272250-9

Language

English

Published

1998

Copyright

Copyright © 1998 Elsevier Inc. All rights reserved

Imprint

Academic Press

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Authors

Shayne C. Gad

Gad Consulting Services, Raleigh, North Carolina

Christopher P. Chengelis

WIL Research Laboratories, Ashland, Ohio