Screening and surveillance colonoscopy with removal of precancerous colon polyps has greatly reduced colon cancer morbidity and mortality and has become an important part of China's new strategy for colon cancer prevention. Colonoscopy with polypectomy could lead to complications such as post-polypectomy hemorrhage and incomplete polyp removal contributing to interval colon cancer development. Polypectomy techniques play an important role. The evolution of different polypectomy techniques and their advantages and disadvantages have been reviewed to help readers choose and apply the best suitable ones for their individual patient situation toward safer and more efficacious colonoscopy polypectomy.