An overview of research related to the use of capillary electrophoresis in the impurity profiling of drugs is presented.
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The principle, instrumentation, and different types of capillary electrophoresis (CE) methods are outlined here.
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Applications of different of CE methods with the chemical structures of drugs and their impurities are highlighted.
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A brief description is also provided on the analysis of Pharmacopeial monographs using CE methods.
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A comparison of CE with liquid chromatography for impurity profiling and analysis of drugs is presented in this review.
Abstract
Capillary electrophoresis (CE) is widely used for the impurity profiling of drugs that contain stereochemical centers in their structures, analysis of biomolecules, and characterization of biopharmaceuticals. Currently, CE is the method of choice for the analysis of foodstuffs and the determination of adulterants. This article discusses the general theory and instrumentation of CE as well as the classification of various CE techniques. It also presents an overview of research on the applications of different CE techniques in the impurity profiling of drugs in the past decade. The review briefly presents a comparison between CE and liquid chromatography methods and highlights the strengths of CE using drug compounds as examples. This review will help scientists, fellow researchers, and students to understand the applications of CE techniques in the impurity profiling of drugs.
