Cover for Cancer Immunotherapy

Cancer Immunotherapy

Immune Suppression and Tumor Growth

Book • Second Edition2013

Edited by:

George C. Prendergast and Elizabeth M. Jaffee

Cancer Immunotherapy

Immune Suppression and Tumor Growth

Book • Second Edition2013

 

Cover for Cancer Immunotherapy

Edited by:

George C. Prendergast and Elizabeth M. Jaffee

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Book description

There has been major growth in understanding immune suppression mechanisms and its relationship to cancer progression and therapy. This book highlights emerging new principles of i ... read full description

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  2. Book chapterAbstract only

    Chapter 1 - Introduction

    George C. Prendergast and Elizabeth M. Jaffee

    Pages 1-8

  3. Book chapterNo access

    Index

    Pages 635-655

About the book

Description

There has been major growth in understanding immune suppression mechanisms and its relationship to cancer progression and therapy. This book highlights emerging new principles of immune suppression that drive cancer, and it offers radically new ideas about how therapy can be improved by attacking these principles. Following work that firmly establishes immune escape as an essential trait of cancer, recent studies have now defined specific mechanisms of tumor immune suppression. It also demonstrates how attacking tumors with molecular targeted therapeutics or traditional chemotherapeutic drugs can produce potent anti-tumor effects in preclinical models. This book provides basic, translational, and clinical cancer researchers with an indispensable overview of immune escape as a critical trait in cancer and how applying specific combinations of immunotherapy and chemotherapy to attack this trait may radically improve the treatment of advanced disease.

There has been major growth in understanding immune suppression mechanisms and its relationship to cancer progression and therapy. This book highlights emerging new principles of immune suppression that drive cancer, and it offers radically new ideas about how therapy can be improved by attacking these principles. Following work that firmly establishes immune escape as an essential trait of cancer, recent studies have now defined specific mechanisms of tumor immune suppression. It also demonstrates how attacking tumors with molecular targeted therapeutics or traditional chemotherapeutic drugs can produce potent anti-tumor effects in preclinical models. This book provides basic, translational, and clinical cancer researchers with an indispensable overview of immune escape as a critical trait in cancer and how applying specific combinations of immunotherapy and chemotherapy to attack this trait may radically improve the treatment of advanced disease.

Key Features

  • Offers a synthesis of concepts that are useful to cancer immunologists and pharmacologists, who tend to work in disparate fields with little cross-communication
  • Drs. Prendergast and Jaffee are internationally recognized leaders in cancer biology and immunology who have created a unique synthesis of fundamental and applied concepts in this important new area of cancer research
  • Summarizes the latest insights into how immune escape defines an essential trait of cancer
  • Includes numerous illustrations, including how molecular-targeted therapeutic drugs or traditional chemotherapy can be combined with immunotherapy to improve anti-tumor efficacy and how reversing immune suppression by the tumor can cause tumor regression
  • Offers a synthesis of concepts that are useful to cancer immunologists and pharmacologists, who tend to work in disparate fields with little cross-communication
  • Drs. Prendergast and Jaffee are internationally recognized leaders in cancer biology and immunology who have created a unique synthesis of fundamental and applied concepts in this important new area of cancer research
  • Summarizes the latest insights into how immune escape defines an essential trait of cancer
  • Includes numerous illustrations, including how molecular-targeted therapeutic drugs or traditional chemotherapy can be combined with immunotherapy to improve anti-tumor efficacy and how reversing immune suppression by the tumor can cause tumor regression

Details

ISBN

978-0-12-394296-8

Language

English

Published

2013

Copyright

Copyright © 2013 Elsevier Inc. All rights reserved.

Imprint

Academic Press

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Editors

George C. Prendergast

The Lankenau Institute for Medical Research Lankenau Cancer Center Wynnewood, PA

Elizabeth M. Jaffee

The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Medical Institute Bunting-Blaustein Cancer Research Building Baltimore, MD