Cover for Biased Signaling in Physiology, Pharmacology and Therapeutics

Biased Signaling in Physiology, Pharmacology and Therapeutics

Book2014

Edited by:

Brian J. Arey

Biased Signaling in Physiology, Pharmacology and Therapeutics

Book2014

 

Cover for Biased Signaling in Physiology, Pharmacology and Therapeutics

Edited by:

Brian J. Arey

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Book description

Biased Signaling in Physiology, Pharmacology and Therapeutics is a unique and essential reference for the scientific community concerning how conformational-dependent activation is ... read full description

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  2. Book chapterAbstract only

    Chapter 1 - An Historical Introduction to Biased Signaling

    Brian J. Arey

    Pages 1-39

  3. Book chapterAbstract only

    Chapter 2 - The Role of the Cell Background in Biased Signaling

    Guillermo G. Romero

    Pages 41-79

  4. Book chapterAbstract only

    Chapter 3 - The Application of Signaling Bias to New Therapeutic Drug Therapy for Seven Transmembrane (G Protein-coupled) Receptors: Quantifying Bias

    Terry Kenakin

    Pages 81-102

  5. Book chapterAbstract only

    Chapter 4 - Biased Signaling and Conformational Dynamics in Nuclear Hormone Receptors

    Colin A. Flaveny, Laura A. Solt, ... Thomas P. Burris

    Pages 103-135

  6. Book chapterAbstract only

    Chapter 5 - Biasing Receptor Tyrosine Kinase Signaling Pathways

    John Watson, Brian J. Arey and Andrew Alt

    Pages 137-172

  7. Book chapterAbstract only

    Chapter 6 - Conformational Mechanisms of Signaling Bias of Ion Channels

    James Herrington and Brian J. Arey

    Pages 173-207

  8. Book chapterAbstract only

    Chapter 7 - Protein Conformational Dynamics and Signaling in Evolution and Pathophysiology

    Liang Schweizer and Luciano Mueller

    Pages 209-249

  9. Book chapterAbstract only

    Chapter 8 - Promises of Biased Signaling in the Development of Improved Therapeutics

    Barbara Bosier and Emmanuel Hermans

    Pages 251-292

  10. Book chapterNo access

    Index

    Pages 293-300

About the book

Description

Biased Signaling in Physiology, Pharmacology and Therapeutics is a unique and essential reference for the scientific community concerning how conformational-dependent activation is a common phenomenon across many classes of receptors or signaling molecules. It discusses the role of conformational dynamics in leading to signaling bias across different classes of receptors and signaling molecules. By providing a broader view of signaling bias, this resource helps to explain common mechanisms shared across receptor classes and how this can be utilized to elucidate their cellular activity and better understand their therapeutic potential.

Written for both new and established scientists in pharmacology, cell biology, biochemistry, and signal transduction, as well as physicians, this book clearly illustrates how biased receptor signaling can be utilized to develop and understand complex pharmacology. Chapters are each focused on a specific class of receptor or other important topic and make use of real-world examples illustrating how the latest research in signal transduction has led to a better understanding of pharmacology and cell biology. This structure creates a basis for understanding that physiological signalling bias has been selected by nature in order to provide complex and tissue- specific biological responses in the face of limited receptors and signaling pathways. This book provides a framework to reveal that these physiological mechanisms are not restricted to one receptor type or family and thus presents receptor signaling from a newer, more global perspective.

Biased Signaling in Physiology, Pharmacology and Therapeutics is a unique and essential reference for the scientific community concerning how conformational-dependent activation is a common phenomenon across many classes of receptors or signaling molecules. It discusses the role of conformational dynamics in leading to signaling bias across different classes of receptors and signaling molecules. By providing a broader view of signaling bias, this resource helps to explain common mechanisms shared across receptor classes and how this can be utilized to elucidate their cellular activity and better understand their therapeutic potential.

Written for both new and established scientists in pharmacology, cell biology, biochemistry, and signal transduction, as well as physicians, this book clearly illustrates how biased receptor signaling can be utilized to develop and understand complex pharmacology. Chapters are each focused on a specific class of receptor or other important topic and make use of real-world examples illustrating how the latest research in signal transduction has led to a better understanding of pharmacology and cell biology. This structure creates a basis for understanding that physiological signalling bias has been selected by nature in order to provide complex and tissue- specific biological responses in the face of limited receptors and signaling pathways. This book provides a framework to reveal that these physiological mechanisms are not restricted to one receptor type or family and thus presents receptor signaling from a newer, more global perspective.

Key Features

  • Offers a unique and valuable resource on biased receptor signaling that provides a global view for better understanding pharmacology across many receptor families
  • Integrates biased receptor signaling, physiology, and pharmacology to place this emerging science within the context of treating disease
  • Includes important chapters on both the pharmaceutical and therapeutic implications of biased signaling
  • Offers a unique and valuable resource on biased receptor signaling that provides a global view for better understanding pharmacology across many receptor families
  • Integrates biased receptor signaling, physiology, and pharmacology to place this emerging science within the context of treating disease
  • Includes important chapters on both the pharmaceutical and therapeutic implications of biased signaling

Details

ISBN

978-0-12-411460-9

Language

English

Published

2014

Copyright

Copyright © 2014 Elsevier Inc. All rights reserved.

Imprint

Academic Press

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Editors

Brian J. Arey