Cover for Bacterial Cellular Metabolic Systems

Bacterial Cellular Metabolic Systems

Metabolic Regulation of a Cell System with 13c-Metabolic Flux Analysis

A volume in Woodhead Publishing Series in Biomedicine

Book2013

Authors:

Kazuyuki Shimizu

Bacterial Cellular Metabolic Systems

Metabolic Regulation of a Cell System with 13c-Metabolic Flux Analysis

A volume in Woodhead Publishing Series in Biomedicine

Book2013

 

Cover for Bacterial Cellular Metabolic Systems

Authors:

Kazuyuki Shimizu

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Book description

The metabolic regulation of a cell system is of critical importance in systems biology, and a robust model of these mechanisms is essential in predicting the effects on the metabol ... read full description

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  2. Book chapterAbstract only

    1 - Main metabolism

    Pages 1-54

  3. Book chapterAbstract only

    2 - Brief overview of metabolic regulation of a bacterial cell

    Pages 55-94

  4. Book chapterAbstract only

    3 - Metabolic regulation by global regulators in response to culture environment

    Pages 95-213

  5. Book chapterAbstract only

    4 - Conventional flux balance analysis and its applications

    Pages 215-262

  6. Book chapterAbstract only

    5 - 13C-metabolic flux analysis and its applications

    Pages 263-358

  7. Book chapterAbstract only

    6 - Effect of a specific-gene knockout on metabolism

    Pages 359-447

  8. Book chapterNo access

    Appendices

    Pages 449-461

  9. Book chapterNo access

    Index

    Pages 463-470

About the book

Description

The metabolic regulation of a cell system is of critical importance in systems biology, and a robust model of these mechanisms is essential in predicting the effects on the metabolism of both the culture environment and the knockout of specific genes. Bacterial cellular metabolic systems focuses on this highly topical subject in relation to culture environment and provides a detailed analysis from gene level to metabolic level regulation, as well as offering a discussion of the most recent modelling approaches. The book begins with an introduction to metabolic mechanisms and to the metabolic regulation of a cell, before moving on to discussing the action of global regulators in response to a specific culture environment. The second half of the book examines conventional flux balance analysis and its applications, 13C-metabolic flux analysis, and the effect of a specific gene knockout on the metabolism.

The metabolic regulation of a cell system is of critical importance in systems biology, and a robust model of these mechanisms is essential in predicting the effects on the metabolism of both the culture environment and the knockout of specific genes. Bacterial cellular metabolic systems focuses on this highly topical subject in relation to culture environment and provides a detailed analysis from gene level to metabolic level regulation, as well as offering a discussion of the most recent modelling approaches. The book begins with an introduction to metabolic mechanisms and to the metabolic regulation of a cell, before moving on to discussing the action of global regulators in response to a specific culture environment. The second half of the book examines conventional flux balance analysis and its applications, 13C-metabolic flux analysis, and the effect of a specific gene knockout on the metabolism.

Key Features

  • Comprehensive account of metabolic regulation via global regulators in response to changes in the culture environment
  • Basic formulation of 13C-metabolic flux analysis based on 13C-labelling experiments
  • Systems biology approach for the modelling and computer simulation of the main metabolic pathways of a cell system
  • Comprehensive account of metabolic regulation via global regulators in response to changes in the culture environment
  • Basic formulation of 13C-metabolic flux analysis based on 13C-labelling experiments
  • Systems biology approach for the modelling and computer simulation of the main metabolic pathways of a cell system

Details

ISBN

978-1-907568-01-5

Language

English

Published

2013

Copyright

Copyright © 2013 Woodhead Publishing Limited. All rights reserved.

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Woodhead Publishing

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Authors

Kazuyuki Shimizu