Browse content
Table of contents
Actions for selected chapters
- Full text access
- Book chapterAbstract only
Chapter 1 - Discovery of Qinghaosu (Artemisinin)—History of Research and Development of Artemisinin-Based Antimalarials
Pages 1-67 - Book chapterAbstract only
Chapter 2 - Agronomics and Biology of Artemisia annua L.
Pages 69-128 - Book chapterAbstract only
Chapter 3 - Artemisinin Chemical Research
Pages 129-175 - Book chapterAbstract only
Chapter 4 - Artemisinin Derivatives and Analogues
Li Ying
Pages 177-196 - Book chapterAbstract only
Chapter 5 - Artemisinin and Derivatives: Pharmacodynamics, Toxicology, Pharmacokinetics, Mechanism of Action, Resistance, and Immune Regulation
Pages 197-351 - Book chapterAbstract only
Chapter 6 - Artemisinin and Derivatives: Clinical Studies
Pages 353-413 - Book chapterAbstract only
Chapter 7 - Artemether and Lumefantrine Tablets (Coartem)
Ning Dianxi, Zhong Jingxing and Zeng Meiyi
Pages 415-481 - Book chapterAbstract only
Chapter 8 - Artemisinin–Naphthoquine Phosphate Combination (ARCO)
Pages 483-569 - Book chapterAbstract only
Chapter 9 - Artemisinins and Pyronaridine Phosphate Combination
Chen Chang
Pages 571-607 - Book chapterAbstract only
Chapter 10 - Dihydroartemisinin and Artemisinin in Combination With Piperaquine (Artekin, Artequick); Primaquine and Malaria Transmission; and Malaria Elimination
Pages 609-670 - Book chapterNo access
Index
Pages 671-705
About the book
Description
Artemisinin-Based and Other Antimalarials: Detailed Account of Studies by Chinese Scientists Who Discovered and Developed Them provides a historical and scientific background of the discovery and development of artemisinin, artemisinin derivatives, combination drugs and related chemicals. It is a historical document, a scientific treatise, and a fascinating description of innovative research on new drug development that is carried out under extremely difficult conditions. The book also includes detailed experiments, physical-chemical procedures, practical methodologies and clinical trials. It is a valuable reference for students and researchers in the fields of scientific history, medicine, pharmaceutical science, chemistry, pharmacology and toxicology.
Artemisinin-Based and Other Antimalarials: Detailed Account of Studies by Chinese Scientists Who Discovered and Developed Them provides a historical and scientific background of the discovery and development of artemisinin, artemisinin derivatives, combination drugs and related chemicals. It is a historical document, a scientific treatise, and a fascinating description of innovative research on new drug development that is carried out under extremely difficult conditions. The book also includes detailed experiments, physical-chemical procedures, practical methodologies and clinical trials. It is a valuable reference for students and researchers in the fields of scientific history, medicine, pharmaceutical science, chemistry, pharmacology and toxicology.
Key Features
- Presents details of all stages of drug development, including in vitro experiment, animal exploratory studies, animal tests for toxicity, safety and efficacy followed by stages I, II, III and IV, safety and efficacy in human volunteers and patients with malaria
- Provides many physical-chemical laboratory procedures, such as NMR, MS, HPLC and X-ray diffraction used in drug development
- Includes practical methodology of clinical trials from many research centers and countries to demonstrate the importance of this discovery
- Presents details of all stages of drug development, including in vitro experiment, animal exploratory studies, animal tests for toxicity, safety and efficacy followed by stages I, II, III and IV, safety and efficacy in human volunteers and patients with malaria
- Provides many physical-chemical laboratory procedures, such as NMR, MS, HPLC and X-ray diffraction used in drug development
- Includes practical methodology of clinical trials from many research centers and countries to demonstrate the importance of this discovery
Details
ISBN
978-0-12-813133-6
Language
English
Published
2018
Copyright
Copyright © 2018 Elsevier Inc. All rights reserved.
Imprint
Academic Press