Cover for Artemisinin-Based and Other Antimalarials

Artemisinin-Based and Other Antimalarials

Detailed Account of Studies by Chinese Scientists Who Discovered and Developed Them

Book2018

Edited by:

Li Guoqiao, Li Ying, ... Zeng Meiyi

Artemisinin-Based and Other Antimalarials

Detailed Account of Studies by Chinese Scientists Who Discovered and Developed Them

Book2018

 

Cover for Artemisinin-Based and Other Antimalarials

Edited by:

Li Guoqiao, Li Ying, ... Zeng Meiyi

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Artemisinin-Based and Other Antimalarials: Detailed Account of Studies by Chinese Scientists Who Discovered and Developed Them provides a historical and scientific background of th ... read full description

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  2. Book chapterAbstract only

    Chapter 1 - Discovery of Qinghaosu (Artemisinin)—History of Research and Development of Artemisinin-Based Antimalarials

    Pages 1-67

  3. Book chapterAbstract only

    Chapter 2 - Agronomics and Biology of Artemisia annua L.

    Pages 69-128

  4. Book chapterAbstract only

    Chapter 3 - Artemisinin Chemical Research

    Pages 129-175

  5. Book chapterAbstract only

    Chapter 4 - Artemisinin Derivatives and Analogues

    Li Ying

    Pages 177-196

  6. Book chapterAbstract only

    Chapter 5 - Artemisinin and Derivatives: Pharmacodynamics, Toxicology, Pharmacokinetics, Mechanism of Action, Resistance, and Immune Regulation

    Pages 197-351

  7. Book chapterAbstract only

    Chapter 6 - Artemisinin and Derivatives: Clinical Studies

    Pages 353-413

  8. Book chapterAbstract only

    Chapter 7 - Artemether and Lumefantrine Tablets (Coartem)

    Ning Dianxi, Zhong Jingxing and Zeng Meiyi

    Pages 415-481

  9. Book chapterAbstract only

    Chapter 8 - Artemisinin–Naphthoquine Phosphate Combination (ARCO)

    Pages 483-569

  10. Book chapterAbstract only

    Chapter 9 - Artemisinins and Pyronaridine Phosphate Combination

    Chen Chang

    Pages 571-607

  11. Book chapterAbstract only

    Chapter 10 - Dihydroartemisinin and Artemisinin in Combination With Piperaquine (Artekin, Artequick); Primaquine and Malaria Transmission; and Malaria Elimination

    Pages 609-670

  12. Book chapterNo access

    Index

    Pages 671-705

About the book

Description

Artemisinin-Based and Other Antimalarials: Detailed Account of Studies by Chinese Scientists Who Discovered and Developed Them provides a historical and scientific background of the discovery and development of artemisinin, artemisinin derivatives, combination drugs and related chemicals. It is a historical document, a scientific treatise, and a fascinating description of innovative research on new drug development that is carried out under extremely difficult conditions. The book also includes detailed experiments, physical-chemical procedures, practical methodologies and clinical trials. It is a valuable reference for students and researchers in the fields of scientific history, medicine, pharmaceutical science, chemistry, pharmacology and toxicology.

Artemisinin-Based and Other Antimalarials: Detailed Account of Studies by Chinese Scientists Who Discovered and Developed Them provides a historical and scientific background of the discovery and development of artemisinin, artemisinin derivatives, combination drugs and related chemicals. It is a historical document, a scientific treatise, and a fascinating description of innovative research on new drug development that is carried out under extremely difficult conditions. The book also includes detailed experiments, physical-chemical procedures, practical methodologies and clinical trials. It is a valuable reference for students and researchers in the fields of scientific history, medicine, pharmaceutical science, chemistry, pharmacology and toxicology.

Key Features

  • Presents details of all stages of drug development, including in vitro experiment, animal exploratory studies, animal tests for toxicity, safety and efficacy followed by stages I, II, III and IV, safety and efficacy in human volunteers and patients with malaria
  • Provides many physical-chemical laboratory procedures, such as NMR, MS, HPLC and X-ray diffraction used in drug development
  • Includes practical methodology of clinical trials from many research centers and countries to demonstrate the importance of this discovery
  • Presents details of all stages of drug development, including in vitro experiment, animal exploratory studies, animal tests for toxicity, safety and efficacy followed by stages I, II, III and IV, safety and efficacy in human volunteers and patients with malaria
  • Provides many physical-chemical laboratory procedures, such as NMR, MS, HPLC and X-ray diffraction used in drug development
  • Includes practical methodology of clinical trials from many research centers and countries to demonstrate the importance of this discovery

Details

ISBN

978-0-12-813133-6

Language

English

Published

2018

Copyright

Copyright © 2018 Elsevier Inc. All rights reserved.

Imprint

Academic Press

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Editors

Li Guoqiao

Li Ying

Li Zelin

Zeng Meiyi