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CHAPTER 1 - A BRIEF HISTORY OF CANCER CHEMOTHERAPY
Bruce C. Baguley
Pages 1-11 - Book chapterNo access
CHAPTER 2 - NOVEL TARGETS IN THE CELL CYCLE AND CELL CYCLE CHECKPOINTS
Yves Pommier, Qiang Yu and Kurt W. Kohn
Pages 13-cp2 - Book chapterNo access
CHAPTER 3 - GROWTH FACTOR AND SIGNAL TRANSDUCTION TARGETS FOR CANCER THERAPY
W.R. Leopold, Alex Bridges, ... Judith Sebolt-Leopold
Pages 31-53 - Book chapterNo access
CHAPTER 4 - CELL DEATH PATHWAYS AS TARGETS FOR ANTICANCER DRUGS
Eric Solary, Nathalie Droin, ... Patrick Ducoroy
Pages 55-76 - Book chapterNo access
CHAPTER 5 - DRUG RESISTANCE PATHWAYS AS TARGETS
Akihiro Tomida and Takashi Tsuruo
Pages 77-90 - Book chapterNo access
CHAPTER 6 - ROLE OF MATRIX METALLOPROTEINASES AND PLASMINOGEN ACTIVATORS IN CANCER INVASION AND METASTASIS: THERAPEUTIC STRATEGIES
Stanley Zucker, Jian Cao and Christopher J. Molloy
Pages 91-122 - Book chapterNo access
CHAPTER 7 - TUMOR VASCULATURE AS A TARGET
Elianne A. Koop and Emile E. Voest
Pages 123-cp2 - Book chapterNo access
CHAPTER 8 - GENE-DIRECTED ENZYME PRODRUG THERAPY
Caroline J. Springer and Ion Niculescu-Duvaz
Pages 137-155 - Book chapterNo access
CHAPTER 9 - TUMOR ANTIGENS AS TARGETS FOR ANTICANCER DRUG DEVELOPMENT
Mario Sznol and Thomas Davis
Pages 157-170 - Book chapterNo access
CHAPTER 10 - STRUCTURE-BASED DRUG DESIGN AND ITS CONTRIBUTIONS TO CANCER CHEMOTHERAPY
Robert C. Jackson
Pages 171-cp1 - Book chapterNo access
CHAPTER 11 - THE CONTRIBUTION OF SYNTHETIC ORGANIC CHEMISTRY TO ANTICANCER DRUG DEVELOPMENT
William A Denny
Pages 187-202 - Book chapterNo access
CHAPTER 12 - BIOSYNTHETIC PRODUCTS FOR ANTICANCER DRUG DESIGN AND TREATMENT: THE BRYOSTATINS
George R. Pettit, Cherry L. Herald and Fiona Hogan
Pages 203-235 - Book chapterNo access
CHAPTER 13 - DNA-ENCODED PEPTIDE LIBRARIES AND DRUG DISCOVERY
Sachdev S. Sidhu and Gregory A. Weiss
Pages 237-248 - Book chapterNo access
CHAPTER 14 - MECHANISM-BASED HIGH-THROUGHPUT SCREENING FOR NOVEL ANTICANCER DRUG DISCOVERY
Wynne Aherne, Michelle Garrett, ... Paul Workman
Pages 249-267 - Book chapterNo access
CHAPTER 15 - TUMOR CELL CULTURES IN DRUG DEVELOPMENT
Bruce C. Baguley, Kevin O. Hicks and William R. Wilson
Pages 269-cp1 - Book chapterNo access
CHAPTER 16 - SCREENING USING ANIMAL SYSTEMS
Angelika M. Burger and Heinz-Herbert Fiebig
Pages 285-299 - Book chapterNo access
CHAPTER 17 - RELEVANCE OF PRECLINICAL PHARMACOLOGY AND TOXICOLOGY TO PHASE I TRIAL EXTRAPOLATION TECHNIQUES: RELEVANCE OF ANIMAL TOXICOLOGY
Joseph E. Tomaszewski, Adaline C. Smith, ... Karen M. Schweikart
Pages 301-328 - Book chapterNo access
CHAPTER 18 - CLINICAL TRIAL DESIGN: INCORPORATION OF PHARMACOKINETIC, PHARMACODYNAMIC, AND PHARMACOGENETIC PRINCIPLES
Alex Sparreboom, Walter J. Loos, ... Jaap Verweij
Pages 329-351 - Book chapterNo access
CHAPTER 19 - TUMOR IMAGING APPLICATIONS IN THE TESTING OF NEW DRUGS
Eric Ofori Aboagye, Azeem Saleem and Patricia M. Price
Pages 353-cp3 - Book chapterNo access
CHAPTER 20 - MECHANISTIC APPROACHES TO PHASE I CLINICAL TRIALS
David R. Ferry and David J. Kerr
Pages 371-384 - Book chapterNo access
INDEX
Pages 385-397
About the book
Description
Here in a single source is a complete spectrum of ideas on the development of new anticancer drugs. Containing concise reviews of multidisciplinary fields of research, this book offers a wealth of ideas on current and future molecular targets for drug design, including signal transduction, the cell division cycle, and programmed cell death. Detailed descriptions of sources for new drugs and methods for testing and clinical trial design are also provided.
Here in a single source is a complete spectrum of ideas on the development of new anticancer drugs. Containing concise reviews of multidisciplinary fields of research, this book offers a wealth of ideas on current and future molecular targets for drug design, including signal transduction, the cell division cycle, and programmed cell death. Detailed descriptions of sources for new drugs and methods for testing and clinical trial design are also provided.
Key Features
- One work that can be consulted for all aspects of anticancer drug development
- Concise reviews of research fields, combined with practical scientific detail, written by internationally respected experts
- A wealth of ideas on current and future molecular targets for drug design, including signal transduction, the cell division cycle, and programmed cell death
- Detailed descriptions of the sources of new anticancer drugs, including combinatorial chemistry, phage display, and natural products
- Discussion of how new drugs can be tested in preclinical systems, including the latest technology of robotic assay systems, cell culture, and experimental animal techniques
- Hundreds of references that allow the reader to access relevant scientific and medical literature
- Clear illustrations, some in color, that provide both understanding of the field and material for teaching
- One work that can be consulted for all aspects of anticancer drug development
- Concise reviews of research fields, combined with practical scientific detail, written by internationally respected experts
- A wealth of ideas on current and future molecular targets for drug design, including signal transduction, the cell division cycle, and programmed cell death
- Detailed descriptions of the sources of new anticancer drugs, including combinatorial chemistry, phage display, and natural products
- Discussion of how new drugs can be tested in preclinical systems, including the latest technology of robotic assay systems, cell culture, and experimental animal techniques
- Hundreds of references that allow the reader to access relevant scientific and medical literature
- Clear illustrations, some in color, that provide both understanding of the field and material for teaching
Details
ISBN
978-0-12-072651-6
Language
English
Published
2002
Copyright
Copyright © 2002 Elsevier Inc. All rights reserved
Imprint
Academic Press