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Chapter 1 - Introduction to clinical pharmacology
Arthur J. Atkinson
Pages 1-10 - Book chapterAbstract only
Chapter 2 - Clinical pharmacokinetics
Arthur J. Atkinson
Pages 11-26 - Book chapterAbstract only
Chapter 3 - Compartmental analysis of drug distribution
Arthur J. Atkinson
Pages 27-42 - Book chapterAbstract only
Chapter 4 - Drug absorption and bioavailability
Arthur J. Atkinson
Pages 43-59 - Book chapterAbstract only
Chapter 5 - Effect of kidney disease on pharmacokinetics
Thomas D. Nolin, Albert W. Dreisbach, ... Juan J.L. Lertora
Pages 61-72 - Book chapterAbstract only
Chapter 6 - Pharmacokinetics in patients requiring renal replacement therapy
Arthur J. Atkinson, Thomas D. Nolin and John M. Allen
Pages 73-90 - Book chapterAbstract only
Chapter 7 - Effect of liver disease on pharmacokinetics
Nathalie K. Zgheib, Juan J.L. Lertora and Robert A. Branch
Pages 91-112 - Book chapterAbstract only
Chapter 8 - Noncompartmental and compartmental approaches to pharmacokinetic data analysis
David M. Foster and Paolo Vicini
Pages 113-135 - Book chapterAbstract only
Chapter 9 - Population pharmacokinetics
Ophelia Yin and Raymond Miller
Pages 137-150 - Book chapterAbstract only
Chapter 10 - Pathways of drug metabolism
R. Scott Obach and Nina Isoherranen
Pages 151-168 - Book chapterAbstract only
Chapter 11 - Bioanalytical methods: Technological platforms and method validation
Mark E. Arnold and Brian Booth
Pages 169-187 - Book chapterAbstract only
Chapter 12 - Clinical pharmacogenetics
Anuradha Ramamoorthy, Tristan Sissung and Michael Pacanowski
Pages 189-212 - Book chapterAbstract only
Chapter 13 - Mechanisms and genetics of drug transport
Lei Zhang, Osatohanmwen J. Enogieru, ... Kathleen M. Giacomini
Pages 213-239 - Book chapterAbstract only
Chapter 14 - Drug-drug interactions
Aleksandra Galetin, Lei Zhang, ... Shiew-Mei Huang
Pages 241-265 - Book chapterAbstract only
Chapter 15 - Biochemical mechanisms of drug toxicity
Jack Uetrecht, Denis M. Grant and Peter G. Wells
Pages 267-302 - Book chapterAbstract only
Chapter 16 - Pharmacogenomic mechanisms of drug toxicity
Shiew-Mei Huang, Ligong Chen and Kathleen M. Giacomini
Pages 303-322 - Book chapterAbstract only
Chapter 17 - Biomarkers in drug development
Robert N. Schuck, Jana G. Delfino, ... John A. Wagner
Pages 323-342 - Book chapterAbstract only
Chapter 18 - Imaging in drug development
Owen Carmichael
Pages 343-358 - Book chapterAbstract only
Chapter 19 - Dose-effect and concentration-effect analysis
Jiang Liu, Justin C. Earp, ... Yaning Wang
Pages 359-376 - Book chapterAbstract only
Chapter 20 - Time course of drug response
Nicholas H.G. Holford
Pages 377-387 - Book chapterAbstract only
Chapter 21 - Disease progress models
Diane R. Mould, Nicholas H.G. Holford and Carl C. Peck
Pages 389-403 - Book chapterAbstract only
Chapter 22 - Sex-specific pharmacological differences
Karen D. Vo and Mary F. Paine
Pages 405-424 - Book chapterAbstract only
Chapter 23 - Drug therapy in pregnant and nursing women
Catherine S. Stika and Marilynn C. Frederiksen
Pages 425-454 - Book chapterAbstract only
Chapter 24 - Pediatric clinical pharmacology and therapeutics
Bridgette L. Jones, John N. van Den Anker, ... Gregory L. Kearns
Pages 455-477 - Book chapterAbstract only
Chapter 25 - Medication therapy in older adults
S.W. Johnny Lau, Danijela Gnjidic and Darrell R. Abernethy
Pages 479-498 - Book chapterAbstract only
Chapter 26 - Clinical analysis of adverse drug reactions and pharmacovigilance
Christine Chamberlain, Cindy Kortepeter and Monica Muñoz
Pages 499-517 - Book chapterAbstract only
Chapter 27 - Quality assessment of drug therapy
Charles E. Daniels
Pages 519-536 - Book chapterAbstract only
Chapter 28 - Portfolio and project planning and management in the drug discovery, evaluation, development, and regulatory review process
Charles Grudzinskas, Michael Dyszel, ... Charles T. Gombar
Pages 537-562 - Book chapterAbstract only
Chapter 29 - Drug discovery
Thomas J. Bateman
Pages 563-572 - Book chapterAbstract only
Chapter 30 - Nonclinical drug development
Chris H. Takimoto, Michael J. Wick, ... Denise Jin
Pages 573-588 - Book chapterAbstract only
Chapter 31 - Preclinical prediction of human pharmacokinetics
Malcolm Rowland
Pages 589-601 - Book chapterAbstract only
Chapter 32 - Phase 1 clinical studies
Robert Joseph Noveck and Martina Dagmar Sahre
Pages 603-609 - Book chapterAbstract only
Chapter 33 - Pharmacokinetic and pharmacodynamic considerations in the development of biotechnology products and large molecules
Pamela D. Garzone and Yow-Ming C. Wang
Pages 611-651 - Book chapterAbstract only
Chapter 34 - Design of clinical development programs
Megan A. Gibbs, Bengt Hamren, ... Renee Iacona
Pages 653-679 - Book chapterAbstract only
Chapter 35 - The role of the FDA in guiding drug development
Elimika Pfuma Fletcher, Rajanikanth Madabushi, ... Shiew-Mei Huang
Pages 681-690 - Book chapterAbstract only
Chapter 36 - Emerging clinical pharmacology topics in drug development and precision medicine
Qi Liu, Jack A Gilbert, ... M. Khair ElZarrad
Pages 691-708 - Book chapterNo access
Appendix I - Abbreviated table of Laplace transforms
Page 709 - Book chapterNo access
Appendix II - Answers to study problems—Chapters 2–5
Arthur J. Atkinson
Pages 711-720 - Book chapterNo access
Index
Pages 721-739
About the book
Description
Atkinson’s Principles of Clinical Pharmacology, Fourth Edition is the essential reference on the pharmacologic principles underlying the individualization of patient therapy and contemporary drug development. This well-regarded survey continues to focus on the basics of clinical pharmacology for the development, evaluation and clinical use of pharmaceutical products while also addressing the most recent advances in the field. Written by leading experts in academia, industry, clinical and regulatory settings, the fourth edition has been thoroughly updated to provide readers with an ideal reference on the wide range of important topics impacting clinical pharmacology.
Atkinson’s Principles of Clinical Pharmacology, Fourth Edition is the essential reference on the pharmacologic principles underlying the individualization of patient therapy and contemporary drug development. This well-regarded survey continues to focus on the basics of clinical pharmacology for the development, evaluation and clinical use of pharmaceutical products while also addressing the most recent advances in the field. Written by leading experts in academia, industry, clinical and regulatory settings, the fourth edition has been thoroughly updated to provide readers with an ideal reference on the wide range of important topics impacting clinical pharmacology.
Key Features
- Presents the essential knowledge for effective practice of clinical pharmacology
- Includes a new chapter and extended discussion on the role of personalized and precision medicine in clinical pharmacology
- Offers an extensive regulatory section that addresses US and international issues and guidelines
- Provides extended coverage of earlier chapters on transporters, pharmacogenetics and biomarkers, along with further discussion on "Phase 0" studies (microdosing) and PBPK
- Presents the essential knowledge for effective practice of clinical pharmacology
- Includes a new chapter and extended discussion on the role of personalized and precision medicine in clinical pharmacology
- Offers an extensive regulatory section that addresses US and international issues and guidelines
- Provides extended coverage of earlier chapters on transporters, pharmacogenetics and biomarkers, along with further discussion on "Phase 0" studies (microdosing) and PBPK
Details
ISBN
978-0-12-819869-8
Language
English
Published
2021
Copyright
Copyright © 2022 Elsevier Inc. All rights reserved.
Imprint
Academic Press