Cover for Anticancer Drug Development

Anticancer Drug Development

Book2002

Edited by:

Bruce C. Baguley and David J. Kerr

Anticancer Drug Development

Book2002

 

Cover for Anticancer Drug Development

Edited by:

Bruce C. Baguley and David J. Kerr

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Book description

Here in a single source is a complete spectrum of ideas on the development of new anticancer drugs. Containing concise reviews of multidisciplinary fields of research, this book of ... read full description

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  2. Book chapterNo access

    CHAPTER 1 - A BRIEF HISTORY OF CANCER CHEMOTHERAPY

    Bruce C. Baguley

    Pages 1-11

  3. Book chapterNo access

    CHAPTER 2 - NOVEL TARGETS IN THE CELL CYCLE AND CELL CYCLE CHECKPOINTS

    Yves Pommier, Qiang Yu and Kurt W. Kohn

    Pages 13-cp2

  4. Book chapterNo access

    CHAPTER 3 - GROWTH FACTOR AND SIGNAL TRANSDUCTION TARGETS FOR CANCER THERAPY

    W.R. Leopold, Alex Bridges, ... Judith Sebolt-Leopold

    Pages 31-53

  5. Book chapterNo access

    CHAPTER 4 - CELL DEATH PATHWAYS AS TARGETS FOR ANTICANCER DRUGS

    Eric Solary, Nathalie Droin, ... Patrick Ducoroy

    Pages 55-76

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    CHAPTER 5 - DRUG RESISTANCE PATHWAYS AS TARGETS

    Akihiro Tomida and Takashi Tsuruo

    Pages 77-90

  7. Book chapterNo access

    CHAPTER 6 - ROLE OF MATRIX METALLOPROTEINASES AND PLASMINOGEN ACTIVATORS IN CANCER INVASION AND METASTASIS: THERAPEUTIC STRATEGIES

    Stanley Zucker, Jian Cao and Christopher J. Molloy

    Pages 91-122

  8. Book chapterNo access

    CHAPTER 7 - TUMOR VASCULATURE AS A TARGET

    Elianne A. Koop and Emile E. Voest

    Pages 123-cp2

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    CHAPTER 8 - GENE-DIRECTED ENZYME PRODRUG THERAPY

    Caroline J. Springer and Ion Niculescu-Duvaz

    Pages 137-155

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    CHAPTER 9 - TUMOR ANTIGENS AS TARGETS FOR ANTICANCER DRUG DEVELOPMENT

    Mario Sznol and Thomas Davis

    Pages 157-170

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    CHAPTER 10 - STRUCTURE-BASED DRUG DESIGN AND ITS CONTRIBUTIONS TO CANCER CHEMOTHERAPY

    Robert C. Jackson

    Pages 171-cp1

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    CHAPTER 11 - THE CONTRIBUTION OF SYNTHETIC ORGANIC CHEMISTRY TO ANTICANCER DRUG DEVELOPMENT

    William A Denny

    Pages 187-202

  13. Book chapterNo access

    CHAPTER 12 - BIOSYNTHETIC PRODUCTS FOR ANTICANCER DRUG DESIGN AND TREATMENT: THE BRYOSTATINS

    George R. Pettit, Cherry L. Herald and Fiona Hogan

    Pages 203-235

  14. Book chapterNo access

    CHAPTER 13 - DNA-ENCODED PEPTIDE LIBRARIES AND DRUG DISCOVERY

    Sachdev S. Sidhu and Gregory A. Weiss

    Pages 237-248

  15. Book chapterNo access

    CHAPTER 14 - MECHANISM-BASED HIGH-THROUGHPUT SCREENING FOR NOVEL ANTICANCER DRUG DISCOVERY

    Wynne Aherne, Michelle Garrett, ... Paul Workman

    Pages 249-267

  16. Book chapterNo access

    CHAPTER 15 - TUMOR CELL CULTURES IN DRUG DEVELOPMENT

    Bruce C. Baguley, Kevin O. Hicks and William R. Wilson

    Pages 269-cp1

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    CHAPTER 16 - SCREENING USING ANIMAL SYSTEMS

    Angelika M. Burger and Heinz-Herbert Fiebig

    Pages 285-299

  18. Book chapterNo access

    CHAPTER 17 - RELEVANCE OF PRECLINICAL PHARMACOLOGY AND TOXICOLOGY TO PHASE I TRIAL EXTRAPOLATION TECHNIQUES: RELEVANCE OF ANIMAL TOXICOLOGY

    Joseph E. Tomaszewski, Adaline C. Smith, ... Karen M. Schweikart

    Pages 301-328

  19. Book chapterNo access

    CHAPTER 18 - CLINICAL TRIAL DESIGN: INCORPORATION OF PHARMACOKINETIC, PHARMACODYNAMIC, AND PHARMACOGENETIC PRINCIPLES

    Alex Sparreboom, Walter J. Loos, ... Jaap Verweij

    Pages 329-351

  20. Book chapterNo access

    CHAPTER 19 - TUMOR IMAGING APPLICATIONS IN THE TESTING OF NEW DRUGS

    Eric Ofori Aboagye, Azeem Saleem and Patricia M. Price

    Pages 353-cp3

  21. Book chapterNo access

    CHAPTER 20 - MECHANISTIC APPROACHES TO PHASE I CLINICAL TRIALS

    David R. Ferry and David J. Kerr

    Pages 371-384

  22. Book chapterNo access

    INDEX

    Pages 385-397

About the book

Description

Here in a single source is a complete spectrum of ideas on the development of new anticancer drugs. Containing concise reviews of multidisciplinary fields of research, this book offers a wealth of ideas on current and future molecular targets for drug design, including signal transduction, the cell division cycle, and programmed cell death. Detailed descriptions of sources for new drugs and methods for testing and clinical trial design are also provided.

Here in a single source is a complete spectrum of ideas on the development of new anticancer drugs. Containing concise reviews of multidisciplinary fields of research, this book offers a wealth of ideas on current and future molecular targets for drug design, including signal transduction, the cell division cycle, and programmed cell death. Detailed descriptions of sources for new drugs and methods for testing and clinical trial design are also provided.

Key Features

  • One work that can be consulted for all aspects of anticancer drug development
  • Concise reviews of research fields, combined with practical scientific detail, written by internationally respected experts
  • A wealth of ideas on current and future molecular targets for drug design, including signal transduction, the cell division cycle, and programmed cell death
  • Detailed descriptions of the sources of new anticancer drugs, including combinatorial chemistry, phage display, and natural products
  • Discussion of how new drugs can be tested in preclinical systems, including the latest technology of robotic assay systems, cell culture, and experimental animal techniques
  • Hundreds of references that allow the reader to access relevant scientific and medical literature
  • Clear illustrations, some in color, that provide both understanding of the field and material for teaching
  • One work that can be consulted for all aspects of anticancer drug development
  • Concise reviews of research fields, combined with practical scientific detail, written by internationally respected experts
  • A wealth of ideas on current and future molecular targets for drug design, including signal transduction, the cell division cycle, and programmed cell death
  • Detailed descriptions of the sources of new anticancer drugs, including combinatorial chemistry, phage display, and natural products
  • Discussion of how new drugs can be tested in preclinical systems, including the latest technology of robotic assay systems, cell culture, and experimental animal techniques
  • Hundreds of references that allow the reader to access relevant scientific and medical literature
  • Clear illustrations, some in color, that provide both understanding of the field and material for teaching

Details

ISBN

978-0-12-072651-6

Language

English

Published

2002

Copyright

Copyright © 2002 Elsevier Inc. All rights reserved

Imprint

Academic Press

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Editors

Bruce C. Baguley

Auckland Cancer Society Research Centre, The University of Auckland, Auckland, New Zealand

David J. Kerr

Institute for Cancer Medicine, University of Oxford, Oxford, United Kingdom