Cover for Adverse Events and Oncotargeted Kinase Inhibitors

Adverse Events and Oncotargeted Kinase Inhibitors

Book2017

Authors:

Giuseppe Tridente

Adverse Events and Oncotargeted Kinase Inhibitors

Book2017

 

Cover for Adverse Events and Oncotargeted Kinase Inhibitors

Authors:

Giuseppe Tridente

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Book description

Adverse Events and Oncotargeted Kinase Inhibitors gathers and evaluates data on adverse events associated with tyrosine kinase inhibitors (TKIs), a powerful anti-tumor drug class t ... read full description

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    Index

    Pages 707-715

About the book

Description

Adverse Events and Oncotargeted Kinase Inhibitors gathers and evaluates data on adverse events associated with tyrosine kinase inhibitors (TKIs), a powerful anti-tumor drug class that has recently been introduced for human therapy. This book compiles a comprehensive safety profile of each TKI from experiences in official therapeutic indications, also exploring off-label exploratory investigations and postmarketing pharmaceutical surveillance databases.

A brief history of each drug’s development and submission is provided, along with a more detailed analysis of the mechanism(s) of action involved in therapeutic activity or related to the insurgence of specific adverse events. Early chapters focus on general characteristics of TKIs, typology, and classification of adverse events, while the final chapters analyze TKIs as AE inducers and classes of AEs by system or organ involvement.

This comprehensive resource compiles and critically reviews all of the relevant safety data for this class of drugs, with the goal of improving the understanding of pathogenesis and facilitating the prevention, monitoring, and management of these adverse events.

Adverse Events and Oncotargeted Kinase Inhibitors gathers and evaluates data on adverse events associated with tyrosine kinase inhibitors (TKIs), a powerful anti-tumor drug class that has recently been introduced for human therapy. This book compiles a comprehensive safety profile of each TKI from experiences in official therapeutic indications, also exploring off-label exploratory investigations and postmarketing pharmaceutical surveillance databases.

A brief history of each drug’s development and submission is provided, along with a more detailed analysis of the mechanism(s) of action involved in therapeutic activity or related to the insurgence of specific adverse events. Early chapters focus on general characteristics of TKIs, typology, and classification of adverse events, while the final chapters analyze TKIs as AE inducers and classes of AEs by system or organ involvement.

This comprehensive resource compiles and critically reviews all of the relevant safety data for this class of drugs, with the goal of improving the understanding of pathogenesis and facilitating the prevention, monitoring, and management of these adverse events.

Key Features

  • Offers a unique and comprehensive publication on the adverse events associated with a new and fast-growing class of medicines
  • Provides a systematic analysis of adverse events aimed at better prevention through understanding and offering insights for the development of safer drugs
  • Uses practical guidelines to establish a leading reference on this class of drugs for educators, researchers, drug developers, clinicians, safety professionals, and more
  • Offers a unique and comprehensive publication on the adverse events associated with a new and fast-growing class of medicines
  • Provides a systematic analysis of adverse events aimed at better prevention through understanding and offering insights for the development of safer drugs
  • Uses practical guidelines to establish a leading reference on this class of drugs for educators, researchers, drug developers, clinicians, safety professionals, and more

Details

ISBN

978-0-12-809400-6

Language

English

Published

2017

Copyright

Copyright © 2017 Elsevier Inc. All rights reserved.

Imprint

Academic Press

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Authors

Giuseppe Tridente

Professor Emeritus of Immunology and Pathology, School of Medicine and Surgery, Università degli Studi di Verona, Italy